Synergistic Interaction between the Two Mechanisms of Action of Tapentadol in Analgesia
نویسندگان
چکیده
منابع مشابه
Synergistic interaction between the two mechanisms of action of tapentadol in analgesia.
The novel centrally acting analgesic tapentadol [(-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride] combines two mechanisms of action, μ-opioid receptor (MOR) agonism and noradrenaline reuptake inhibition (NRI), in a single molecule. Pharmacological antagonism studies have demonstrated that both mechanisms of action contribute to the analgesic effects of tapentadol. T...
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ژورنال
عنوان ژورنال: Journal of Pharmacology and Experimental Therapeutics
سال: 2011
ISSN: 0022-3565,1521-0103
DOI: 10.1124/jpet.110.175042